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KMID : 0617219960070010045
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Duksung Bulletin Phamaceutical Sciences
1996 Volume.7 No. 1 p.45 ~ p.53
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Synthesis of (－)－5－(p－Chlorobiphenyl)－3,4－dihydroxy－2(5H)－furanone
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Abstract
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A new method for the synthesis of chiral (-)-5-(p-chlorobiphenyl)-3,4- dihydroxy-2(5H)-furanone (5) is described. The object compound was synthesized from corresponding aldehyde. 4-Hydroxy-2(5H)-furanone is a α,β-unsaturated β-hydroxybutyrolactone, which is also named as a tetronic acid. In many natural products the tetronic acid component was found. The best known of which is ascorbic acid(vitamin C). The new compound (5) that can be construed as a "lipophilic vitamin C analogue", is expected to show antilipidemic and antiaggregatory activities as well as 5-(p-chlorophenyl)-3, 4-dihydroxy-2(5H)-furanone.
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KEYWORD
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